E1 - Reese Witherspoon

Aired: September 15, 2015

Reese Witherspoon serves as the celebrity guest announcer during the series premiere of this variety show hosted by Neil Patrick Harris, which features A-list stars, performances, stunts, comedy skits, mini game shows, audience giveaways and hidden camera pranks. Based on the British series "Ant & Dec's Saturday Night Takeaway."

E2 - Alec Baldwin

Aired: September 22, 2015

Emmy Award winner Alec Baldwin serves as this week's celebrity guest announcer.

E3 - Tyler Perry

Aired: September 29, 2015

Tyler Perry is this week's celebrity guest announcer.

E4 - Shaquille O'Neal

Aired: October 06, 2015

Guest announcer Shaq joins Neil for an evening full of fun, games and housewives, with special guests Gloria Estefan, Zachary Levi and Blue Man Group.

E5 - Jack Black

Aired: October 13, 2015

Guest announcer Jack Black plus Olympic Gold medalist Apolo Ohno, and journalists Matt Lauer and Savannah Guthrie.

E6 - Reba

Aired: October 20, 2015

Guest announcer Reba plus singer OMI, and actors Jesse Tyler Ferguson and Jane Krakowski.

E7 - Kelly Ripa

Aired: October 27, 2015

Guest announcer Kelly Ripa plus singer Ray Parker Jr. and journalist Meredith Vieira.

E8 - Kelsey Grammer

Aired: November 03, 2015

Guest announcer Kelsey Grammer, the Backstreet Boys perform, plus Olympic gold medalist Apolo Ohno.