E1 - Sink or Swim

Aired: September 25, 2024

When a commuter ship capsizes, the ED finds itself under water as the staff struggles to treat the influx of new patients and deal with bold new employees taking charge.

E2 - Bite Your Tongue

Aired: October 02, 2024

Lenox continues to rankle Archer as the two tackle their new roles. Ripley faces possible suspension over what really happened to Pawel. Goodwin is forced to make layoffs.

E3 - Trust Fall

Aired: October 09, 2024

Asher treats a woman whose undiagnosed condition threatens the lives of both her and her unborn child. Goodwin receives a chilling message while battling the hospital higher-ups.

E4 - Blurred Lines

Aired: October 16, 2024

A familiar face returns to the ED. Ripley and Charles treat a woman with a rare disorder. Frost suspects that his patient's father is lying about his daughter's condition.

E5 - Bad Habits

Aired: October 23, 2024

Halloween chaos takes over the ED. Asher helps a pregnant woman with an autistic son. Charles clashes with Nurse Jackie on a psych case.

E6 - Forget Me Not

Aired: November 06, 2024

Chicago P.D. steps up Goodwin's security after she's threatened online by a former employee. Archer and Frost treat victims from a disciplinary camp injured during a rockslide. Maggie gets roped into delivering a high schooler's baby.

E7 - Family Matters

Aired: November 13, 2024

Ripley and Frost uncover shocking information that conflicts with their patient's DNR. Asher facilitates an unexpected reunion. The tension between Archer and Lenox comes to a head.

E8 - Love Will Tear Us Apart

Aired: November 20, 2024

Goodwin's troubles persist. Charles clashes with his former resident over a depressed patient. Lenox and Ripley treat a car accident victim who recently reunited with his college sweetheart.

E9 - No Love Lost

Aired: January 08, 2025

The team fights to save the life of one of their own. Frost and Abrams butt heads with their patient. Asher helps a religious young woman with an ectopic pregnancy.

E10 - Broken Hearts

Aired: January 22, 2025

An army of surgeons prepares to separate conjoined twins. Asher reconnects with someone from her past. Archer treats a tyrannical boss with a heart problem.

E11 - In the Trenches (II)

Aired: January 29, 2025

Following the subway tunnel collapse, Ruzek and Kidd treat injured passengers and track down the missing offender. Archer and Frost perform a life-saving amputation. The crossover starts on Chicago Fire S13E11 In the Trenches (I). It continues on Chicago P.D. S12E11 In the Trenches (III).

E12 - In the Wake

Aired: February 05, 2025

Goodwin struggles with the psychological aftermath of her attack. Ripley treats a patient with helicopter parents. An ED staffer makes a mistake that may cost them their job.

E13 - Take a Look in the Mirror

Aired: February 19, 2025

Lenox's mentorship is put to the test. Asher helps a religious young woman with an ectopic pregnancy. Ripley's self-destructive behavior continues to escalate.

E14 - Acid Test

Aired: February 26, 2025

Gaffney gets a surprise visit from a National Accreditation Board of Hospitals representative. Asher and Naomi search for the cause of a young girl's infection. Lenox and Frost work together to save the victim of an accidental shooting.

E15 - Down in a Hole

Aired: March 05, 2025

Ripley struggles to rescue a woman and her daughter trapped in an abandoned well. An old friend from Frost's TV days shadows Maggie. Asher discovers an extremely rare condition in her patient's ultrasound.

E16 - Poster Child

Aired: March 26, 2025

When her former patient returns to Med, Goodwin learns that time doesn't heal all wounds. Frost and Charles treat a patient struggling with his sexuality. Lenox and Abrams work to save a woman who has been in a coma for 20 years.

E17 - The Book of Archer

Aired: April 02, 2025

Charles and Archer treat a heart transplant patient who believes his new heart doesn't want to be in his body. Lenox takes a personal day. Asher discovers a mass on a pregnant woman's ovary.

E18 - Together One Last Time

Aired: April 16, 2025

Asher makes a tough call to save a life. Frost and Ripley treat a young boy with a snake bite. Archer gives Naomi a patient to handle on her own on her last day in the E.D.

E19 - The Stories We Tell Ourselves

Aired: April 23, 2025

Maggie and Goodwin's friendship is tested as tensions rise during the nurses' union's negotiations with the hospital. Ripley and Archer treat a skateboarder struck by an emergency vehicle. Frost helps a young boy abandoned by his mother.

E20 - The Invisible Hand

Aired: May 07, 2025

The hospital faces a staffing crisis as the nurses stage a sick-out. Archer and Frost bet on who can discharge their patients first. Charles' distrust of a patient complicates his treatment.

E21 - Baby Mine...

Aired: May 14, 2025

Maggie and Frost fight to get a pair of lungs for a young cystic fibrosis patient. Asher learns whether she can become a surrogate. Ripley and Morris treat a tech billionaire's daughter as she battles leukemia.

E22 - ...Don't You Cry

Aired: May 21, 2025

Goodwin is tasked with enforcing difficult cuts to hospital personnel. Charles' daughter is hospitalized after a car accident. A transplant patient makes a life-changing decision.