E1 - Episode 1

Aired: April 06, 2021

Sahira is adamant that her father is innocent, Louis discovers Vicky is trapped in a toxic relationship, and Lucky isn't sure if Kian is really clean.

E2 - Episode 2

Aired: April 13, 2021

Dominic pushes Sacha to make an illicit choice, Kian and Chloe make a shocking discovery in theatre, and are the McGerrys at breaking point?

E3 - Episode 3

Aired: April 20, 2021

Louis is trapped as Vicky’s blackmailing escalates, a desperate Dom tries to convince Ange to take his case on, and Kian leads Lucky on a merry dance as he tries to dodge a drugs test.

E4 - Episode 4

Aired: April 27, 2021

Hanssen worries that the upcoming court case will cause more harm than good. Sacha prepares to risk everything for Dom, but is Ange onto them? Fletch tries to get to grips with his new job.

E5 - Episode 5

Aired: May 04, 2021

The cause of Reyhan’s death comes into question, putting Hanssen and Sahira’s relationship at breaking point. Dominic’s new found optimism might be too much too soon. Kian continues to lie to Lucky, but is she about to work out what’s really going on?

E6 - Episode 6

Aired: May 11, 2021

Donna leads the Holby nursing staff in a protest, but will Hanssen be moved by the nurses’ cause or are things about to get much worse for them? Lucky realises that Kian lied to her about where Andrei was staying, and an accidental encounter between Josh and Hanssen threatens to spill both their secrets.

E7 - Episode 7

Aired: May 18, 2021

When a majax strikes Holby – will self-harming Hanssen be heroic enough to ask for help? Secret addict Kian must choose between a young patient and Andrei – can he keep both safe? Thrust into the limelight, Jeong must diagnose a mystery condition – but will Dom help or hinder?

E8 - Episode 8

Aired: May 25, 2021

How far is wannabe consultant Dom willing to go to ensure his path to power? Burying her head in the sand over her BRCA1 diagnosis, can anyone get through to Max? Reeling from Andrei’s sacrifice, is Kian willing to betray Fletch's trust to get what he wants?

E9 - Episode 9

Aired: June 01, 2021

It’s the day of Max’s operation, and Ange and Josh’s relationship deepens. Kian convinces Andrei to return to the hospital to have his surgery, but is it enough to keep Andrei from leaving again?

E10 - Episode 10

Aired: June 08, 2021

Kian faces losing Andrei, just when he thought he had got him back. Dom gets a shock when a patient chooses Sacha as her consultant instead of him. Are Ange and Josh about to lose their jobs over their secret relationship?

E11 - Episode 11

Aired: June 15, 2021

Sparks fly between Kian and Fletch after Evie and Andrei disappear, Sacha and Dom compete for the top job, and Josh tries to win back Ange.

E12 - Episode 12

Aired: June 22, 2021

Defeated Josh questions his place on AAU, and will Fletch unravel when Darwin faces a crisis?

E13 - Episode 13

Aired: June 28, 2021

Lucky tries to overcome her personal crisis by throwing herself into work. A patient accuses Dominic of leaving an unwanted souvenir in his body during an operation. Kylie does her best to interpret Josh’s cryptic warnings over a potential faux pas with Louis.

E14 - Episode 14

Aired: July 07, 2021

Josh’s mum is not impressed that her 20-something son is dating a woman in her forties. The hospital faces an emergency inspection by the CQC, and is a patient lying to the Dom and Jeong about being bitten by a dog?

E15 - Episode 15

Aired: July 13, 2021

Dom’s mum Carole is admitted with a burnt arm, but is she hiding a more serious ailment? Kylie blurts out Ange’s secret to Josh, and Max tries to rally the troops after the disastrous CQC findings. To add to her woes, Sahira’s son turns up drunk, wounded and hiding a dark secret.

E16 - Episode 16

Aired: July 20, 2021

Dom is shocked when he discovers Carole’s secret, Hanssen is torn as to how to handle Abs’s secret, and can Josh prove to Ange that he’s up to the role of being a father?

E17 - Episode 17

Aired: July 27, 2021

Will Holby City’s new director of improvement be able to turn the hospital around? Can Ange put her personal news aside and prove that she runs a tight ship on AAU?

E18 - Episode 18

Aired: August 03, 2021

Hanssen tries to persuade Lucky to return to Holby, and a terminally ill patient advises Kylie to tell Louis how she really feels about him.

E19 - Episode 19

Aired: August 10, 2021

Holby’s new director of improvement is furious when Hanssen attempts to block their plans for AAU. Evie finds herself facing an impossible decision, and time is running out for Chloe to find a suitable candidate for Eli’s medical trial.

E20 - Episode 20

Aired: August 17, 2021

Evie struggles to cope as she is drawn deeper into Jeni’s world. Dom has doubts about mum Carole joining Darwin’s stent trial, and Kylie must overcome her issues with new nurse Mel for the sake of a desperate young patient.

E21 - Episode 21

Aired: August 24, 2021

Assisting in Eli’s experimental stent trial proves to be the hardest professional challenge of Chloe’s life. Can she overcome her fears? Donna’s teenage daughter Mia arrives drunk on the Holby doorstep after a party with Jeni’s dodgy clients, and as Carole’s dementia worsens, Jeong helps Dominic take her on an imaginary trip to the seaside.

E22 - Episode 22

Aired: August 31, 2021

Hanssen trawls hospital CCTV for a potential threat. As Carole’s dementia worsens, taking part in the experimental stent trial becomes increasingly risky. Aleysa, another of Jeni’s girls, is admitted with a suspicious cut on her arm.

E23 - Episode 23

Aired: September 07, 2021

Eli’s experimental stent trail looks like it will be over before it’s begun when his patient takes a turn for the worse. Ange prepares for the life-saving transfusion on her unborn baby, and Lucky uncovers the dark truth behind Jeni’s activities, but at what price?

E24 - Episode 24

Aired: September 14, 2021

Hanssen finds himself in a perilous situation. Will he be rescued in time? Kylie and Dom suspect an elderly patient may be in peril, and Louis fears for Kylie.

E25 - Episode 25

Aired: September 21, 2021

As Jeni starts making plans to send Evie away, will Fletch and Donna find out the dark truth about what she did to their daughters before it’s too late? Jac refuses to listen to Max, who insists she starts looking into alternative treatment options for her tumour, and is new dad Josh really coping as well as Ange thinks he is?

E26 - Episode 26

Aired: September 28, 2021

Fletch confronts Jeni about what she did to Evie. With their latest round of IVF treatment scheduled for today, Amelia springs an awkward surprise on Eli. With Josh pushing himself at work and to be the perfect dad and partner to Ange, an unplanned visit from his mum Elaine leaves her worrying that he might be falling into old habits. What is Josh hiding?

E27 - Episode 27

Aired: October 05, 2021

Donna allows her personal life to affect her work and neglects Lucky. Jac and Josh try to win Holby a place on a cutting-edge therapy study. Kylie discovers that Louis and Mel are still together.

E28 - Episode 28

Aired: October 12, 2021

When Lucky wakes from surgery, Max has to deliver some life-changing news. Josh tries to cope with the pressures of fatherhood and work, and Henrik is shocked when a familiar face returns to Holby.

E29 - Episode 29

Aired: October 19, 2021

Lucky asks Max for an impossible favour. Hanssen reluctantly agrees to mentor a new protege, despite their shared and painful history. Will Ange notice that Josh isn’t handling the pressure before it is too late?

E30 - Episode 30

Aired: October 26, 2021

On Josh’s birthday, a surprise celebration causes him to fall back into dangerous habits. Kylie tries a bold strategy to save Lucky, and Russ and Hanssen find themselves locked in a store cupboard together.

E31 - Episode 31

Aired: November 02, 2021

Will Ollie be able to contain his deep-seated fears? Josh finds an unexpected reason to take the Green War of the Wards challenge seriously. Can Max and Kylie put aside their differences in order to save the planet?

E32 - Episode 32

Aired: November 09, 2021

Amelia must break some devastating news to husband Eli, Ollie's shady past threatens to catch up with him, and will anyone notice that forgotten and forsaken Jeong is in desperate need of a friend?

E33 - Episode 33

Aired: November 16, 2021

Lucky is readmitted to Holby, and Louis learns the truth about her suicidal thoughts. Jac falters just as she’s about to start the proton-beam therapy. Eli persuades Josh he needs to tell Ange about his bulimia.

E34 - Episode 34

Aired: November 23, 2021

Russ learns the truth about Ollie’s relationship with Maisie, while Max and Dom disagree over his diagnosis of a black female patient. Now that Ange knows the truth about Josh’s bulimia, will their relationship survive?

E35 - Episode 35

Aired: November 30, 2021

Eli struggles to focus on the ward as he worries about Amelia’s health. Russ tries to convince Hanssen that he is not irresponsible. Will Josh keep his word and attend therapy for his eating disorder?

E36 - Episode 36

Aired: December 07, 2021

Dom remains in denial about Carole's ailing health, Eli and Amelia face a difficult choice, and Ollie is eager to return to work, but Hanssen has doubts.

E37 - Episode 37

Aired: December 14, 2021

A young cancer patient returns to go under the knife on AAU, Amelia struggles to cope with yet another devastating setback, and Kylie makes a mortifying Secret Santa faux pas.

E38 - Episode 38

Aired: January 04, 2022

Facing a visit from the regulatory body, Jac hopes a complex operation will show Holby at its best. During a surprise inspection, a patient comes into AAU with a suspicious motorbike injury. And can Hanssen and Russ persuade a reluctant patient to accept a lifesaving liver transplant?

E39 - Episode 39

Aired: January 11, 2022

Dom returns from compassionate leave, but Sacha is concerned he isn’t ready. Jac may be prioritising Holby over her own health - is Fletch’s faith in her misplaced?

E40 - Episode 40

Aired: January 18, 2022

Eli is compromised when Jac implores him to perform risky surgery on her. Fetch finds himself seriously considering Regina's job offer.

E41 - Episode 41

Aired: January 25, 2022

As Fletch’s faith in Holby is dented, a job offer from St James’ becomes increasingly appealing. Hanssen discovers Billie’s secret and is reluctant to keep it from her father. Nicky reaches breaking point with Juliet, but is turning to Amelia for support the answer?

E42 - Episode 42

Aired: February 01, 2022

Jac pushes Nicky to overcome her demons and become the doctor she knows she can be. But just how far is Nicky willing to go? Donna feels dejected when she gets no recognition from anyone.

E43 - Episode 43

Aired: February 08, 2022

Jac’s ambitious plans for the hospital are pushing her staff near a breaking point. Donna struggles to balance it all. Will Madge keep her promise to spy for Regina?

E44 - Episode 44

Aired: February 15, 2022

Josh is tested when a familiar face is admitted to AAU. Max has her principles pushed to the limit. Eli wrestles with his conscience as Amelia presses him about Juliet’s future.

E45 - Episode 45

Aired: February 22, 2022

Nicky must find the strength to be a mother to Juliet or give away her baby for good. As the hospital is forced to lock down, Hanssen has to help deliver Billie's baby. As AAU handles the Darwin overflow, Ange notices Madge behaving suspiciously.

E46 - Episode 46

Aired: February 28, 2022

Kylie believes Madge is the victim of domestic abuse, Dom receives a lucrative offer from a private hospital, and Russ needs to proritise being a father to Billie.

E47 - Episode 47

Aired: March 08, 2022

It’s the moment of truth: will Holby finally get itself out of special measures? Meanwhile, Regina puts more pressure on Madge to betray Jac and the hospital.

E48 - Episode 48

Aired: March 15, 2022

Fletch makes a last-ditch attempt to find a surgeon to save Jac’s life. Kylie tries to persuade Jac to visit Madge at home to find out what is behind her betrayal of Holby.

E49 - Episode 49

Aired: March 22, 2022

The team operate on Jac to try to save her life, Josh's relationship with Claudia resurfaces, and Lexy receives good news about a new kidney.

E50 - Episode 50

Aired: March 29, 2022

As the reverberations of Jac’s surgery impact around Darwin and beyond, will life on Wyvern Wing ever be the same again? Series Finale