E1 - The Sticky Mess of Being

Aired: October 13, 2015

Cara is feeling vulnerable after the break-up of her marriage as a car crash brings Mo's friend Sorcha and her surrogate son back to Holby.

E2 - Cover Up

Aired: October 20, 2015

Cara finds herself in a difficult position when Nicole is readmitted to the ward and in labour as Guy tries to cope following the explosion.

E3 - Calling Time

Aired: October 27, 2015

Cara faces awkward questions following Nicole's disappearance and turns to Jed to help as Mo faces giving William back to Brett.

E4 - What It Takes

Aired: November 03, 2015

It is Arthur's first day back at work as he tries to prove that he can cope as Guy's struggle of confidence continues to affect his work.

E5 - Left Behind

Aired: November 10, 2015

Mo heads into work, positively upbeat considering that she will no longer be surrogate mum to William as she is due to give him back to his father. When Brett faces a sudden medical setback and his mother-in-law Viv becomes obstructive, Mo feels she cannot possibly part with her beloved William and decides to abscond with him...

E6 - Beneath the Cover

Aired: November 17, 2015

Nicole's return to AAU makes life more difficult for Cara as Dom's delight at being given a difficult case turns bad when dealing with a difficult patient.

E7 - A Delicate Truth

Aired: November 24, 2015

Jac returns to work on Darwin leading to a battle with Guy over his plans as Morven and Arthur end up clashing over a patient.

E8 - In Which We Serve

Aired: December 01, 2015

Zosia fears that her days on Darwin may be numbered as she tries to impress Jac as Arthur tries to rekindle his friendship with Morven.

E9 - Skin and Blister

Aired: December 08, 2015

Jesse has no choice but to relive some tragic events as he attempts to help the seriously ill sister of a former patient.

E10 - Bad Blood, Fake Snow

Aired: December 15, 2015

Fran steps up her manoeuvres against Jac and after she raises the possibility of a formal complaint from a patient's sister, Hanssen has to take it seriously.

E11 - Blue Christmas

Aired: December 22, 2015

Fran returns to the hospital and takes some drastic action to try and get Jac's attention.

E12 - Beginnings

Aired: December 29, 2015

It looks like Serena is going to spend another New Year's Eve alone but after some revellers at a gig are attacked, fate brings more than just a few casualties onto the hospital.

E13 - Young Hearts, Run Free

Aired: January 05, 2016

Arthur ends up being pushed to the limit after he attempts to win Morven's affections. Zosia has the chance of a prestigious research internship in Edinburgh and has to tell Ollie.

E14 - The Hope That Kills

Aired: January 12, 2016

Guy's career continues to go from strength to strength but there is a cost. Essie lets her personal life affect her professional one as she attempts to deal with a difficult mother and son relationship.

E15 - Sins of Our Fathers

Aired: January 19, 2016

Hanssen gets ready to fly back to Sweden to see his family and becomes suspicious that Guy is attempting to wrest control of the hospital something which Guy later publicly announces. Serena looks for reassurance that Hanssen will stay and fight the battle.

E16 - Kiss and Tell

Aired: January 26, 2016

Back on Keller, Arthur finds himself in a compromising situation by Morven's father as Mo awaits the news if she is pregnant or not.

E17 - Serenity

Aired: February 02, 2016

After an army medic shows up on Darwin Ward, tensions increase for Guy and Ollie. Serena has to make a difficult decision following the discovery of a family secret.

E18 - A Partnership, Literally

Aired: February 09, 2016

Somebody from from Dominic's past makes an unwelcome return and there are some traumatic consequences.

E19 - All That Glitters

Aired: February 16, 2016

Cleared by the police, Dom returns to work but Lee still has the power he needs to hurt him as Austin's condition continues to deteriorate.

E20 - All Fall Down

Aired: February 23, 2016

Bernie starts her first day on the ward trying to put her army life behind her as Arthur's dream of becoming a life donor gets a set back as Serena has to make a decision regarding Jason.

E21 - One Under

Aired: March 01, 2016

Arthur's attempt to save the life of a patient after being hit by a train leaves him burying his head in the sand as Adele ends up getting more than she bargained.

E22 - On The Ropes

Aired: March 08, 2016

Operating on an old school teacher, Ric battles to remain in control as Mo learns that she hasn't won the role of consultant as Serena is worried about introducing Robbie to her family.

E23 - Where We Belong

Aired: March 15, 2016

Bernie ends up having to question what she wants after her future at the hospital is put in doubt. Ollie and Zosia's world is blown apart after a former flame of his shows up.

E24 - Who You Are

Aired: March 22, 2016

Morven is left reeling by a life changing birthday gift as Mo clashes with Sir Dennis over a patient as Ric suffers an emotional outburst.

E25 - A Friend in Need

Aired: March 29, 2016

When Cara makes a move on Raf, complications arise as Arthur receives some shattering news as an old friend of Adele's is admitted to Darwin.

E26 - Handle With Care

Aired: April 05, 2016

Jason shows up on AAU with his seriously ill carer Allan and Serena’s personal involvement manages to affect her professional judgement as Dom tries to support Arthur following the news that his cancer has spread as Cara has her first day on Darwin.

E27 - Dark Night of the Soul

Aired: April 12, 2016

Following the death of his mother, Jesse attempts to reappraise his relationship with his father as Ina is readmitted to Darwin.

E28 - Prioritise the Heart

Aired: April 19, 2016

Bernie has to work alongside an old army colleague and ends up being forced to confront the secrets of the past and face the truth behind her sudden exit from the army as Mr T learns that no one takes him seriously as Serena has a choice to make between her happiness and Jason.

E29 - Out of Sight Out of Mind

Aired: April 26, 2016

Bernie finds herself being served with divorce papers as Austin is admitted in urgent need of a transplant as Zosia persuades a dying patient to act as a guinea pig.

E30 - The Coward's Way

Aired: May 03, 2016

The arrival of her ex sees Bernie trying to keep her secret hidden as the hospital's new psychiatrist Naomi Palmer makes an instant impression on Fletch.

E31 - It Tolls For Thee

Aired: May 10, 2016

Mo finds herself having to listen to her heart instead of her head as Serena's actions leave devastating consequences as Arthur and Morven have a day they won't forget.

E32 - Running Out

Aired: May 17, 2016

Zosia manages to overstep the mark and accuses a patient of a media leak forcing Oliver to deal with an unwelcome dilemma. Zosia comes to a gut-wrenching decision as Serena discovers Bernie is working on AAU, Dominic has to face his fears.

E33 - When I Grow Up

Aired: May 24, 2016

Arthur is determined to proof himself with Hanssen's ambitions as Raf manages to see Naomi in a different light as Oliver tries to get back together with Zosia.

E34 - The Sky Is Falling

Aired: May 31, 2016

Zosia finds herself having to chose between Arthur and her career as Dom finds his loyalty being tested by a familiar face as Bernie finds it hard to find her place on AAU.

E35 - I'll Walk You Home

Aired: June 07, 2016

Zosia begins to question where her loyalties lie as Arthur and Morven have a decision to make as Dom battles his guilt.

E36 - Missing You Already

Aired: June 16, 2016

A major train accident sees Dom with the perfect opportunity to escape back into work mode. Bernie’s husband attempts to to play dirty in the divorce, as he turns her children against her.

E37 - The Lone Ranger

Aired: June 23, 2016

As Jac launches the fully-formed Digby Stent, it looks like that someone has stolen their patent. Dom’s first day back doesn’t go as planned after a forthright new registrar shakes up the ward.

E38 - Another Day in Paradise: Part One

Aired: June 28, 2016

Dominic comes up with a unique way to grieve the loss of his best friend. Raf and Fletch clash after Raf reveals how he really feels about Naomi.

E39 - Another Day in Paradise: Part Two

Aired: July 05, 2016

Jac reaches breaking point when Ollie diverts from her plans.

E40 - Children of Men

Aired: July 12, 2016

Mo struggles with a big choice about her future. Mikey causes more trouble for Fletch.

E41 - A Perfect Life

Aired: July 19, 2016

Essie finds her own life in danger when she tries to help a desperate patient.

E42 - From Bournemouth with Love

Aired: July 26, 2016

Ollie questions his worth on the Darwin team.

E43 - Back in the Ring

Aired: August 02, 2016

Ric questions his surgical skill when he faces losing another young man.

E44 - Indefensible

Aired: August 04, 2016

Bernie faces an ethical dilemma when her wayward son arrives at the hospital.

E45 - Little Acorns

Aired: August 23, 2016

Guy must face his past when an unexpected patient arrives at Holby.

E46 - Fractured

Aired: August 25, 2016

Jac returns from her break but gets a shock when she sees who is working on Darwin.

E47 - Protect and Serve

Aired: August 30, 2016

With Evie still recovering from her fall, Fletch commits to being a better dad.

E48 - Brave New World

Aired: September 06, 2016

Sacha's birthday celebrations don't go quite according to plan.

E49 - Say a Little Prayer

Aired: September 13, 2016

Fletch is recovering from being attacked. Progress stalls when he loses feeling in his feet. As the paralysis spreads, Raf struggles to diagnose the cause. Will he make a breakthrough before it is too late? The passionate courtship of a patient and her beau reminds Zosia what she has lost with Ollie. In the dark about Ollie's relationship with Jasmine, Zosia begins to think about the possibility of reconciliation. A happily engaged patient and her partner present a vision of what might have been for Sacha and Essie. Have they made the right decision in breaking up?

E50 - Emotionally Yours

Aired: September 20, 2016

Dominic is perturbed when Isaac's former surgical mentor is admitted. Despite the existence of a wife, it's clear there's a personal connection between the two men. Is Dom prepared to accept Isaac's past? Jasmine is keen to impress Jac professionally and make a connection with her half-sister personally. But will Jac's public acknowledgement of their relationship bring them together or drive them further apart? Ric is dispatched by Hanssen to deal with the estranged wife of the local MP - the feisty, French Francoise. Will Ric allow himself to succumb to her Gallic charms?

E51 - Life in the Freezer

Aired: September 27, 2016

Mr T comes to Mo's rescue when she fears for her baby's life. Bernie makes a big decision about her future with Serena when an exciting opportunity arises. A big step in his relationship with Isaac puts Dom's friendship with Zosia at risk.

E52 - Snakes and Ladders

Aired: October 04, 2016

An accident in rehab sets back Fletch's recovery, but it's his attitude that proves the biggest obstacle. Can he beat the doom and gloom before pushing away those who are trying to help him? Isaac wants to impress Ric and Dom wants to impress Isaac, but when Dom sidelines his own success to help make Isaac look good they both wind up in trouble. Mo tries to befriend Inga in light of her new role as best man. Her attempts prove futile when she puts her foot in her mouth repeatedly and winds up covered in wee, having made an enemy out of Inga instead.